Basic Atorvastatin Information

• INN (International Nonproprietary Name): Atorvastatin
• Brand names available in Australia: Lipitor, Apo-atorvastatin, and others
• ATC Code: C10AA05
• Forms & dosages: Tablets (10 mg, 20 mg, 40 mg, 80 mg)
• Manufacturers in Australia: Pfizer, Apo, Sandoz
• Registration status in Australia: Registered and TGA-approved
• OTC / Rx classification: Prescription only

Critical Warnings & Restrictions

When considering atorvastatin, some groups face heightened risks. The elderly, pregnant women, and individuals with chronic illnesses require particular caution. For elderly patients, there's a risk of muscle and liver problems, necessitating careful monitoring and regular blood tests. Pregnant women should avoid atorvastatin due to potential harm to the developing fetus, emphasising the importance of consulting with a healthcare professional before starting treatment. Additionally, those with chronic illnesses, particularly liver conditions, are at a higher risk and must be under strict medical supervision.

High-risk Groups (Elderly, Pregnancy, Chronic Illness)

Certain health conditions present serious contraindications when using atorvastatin:

• Pregnancy and breastfeeding
• Severe hepatic or renal impairment
• Active liver disease

Interaction With Activities (Driving, Workplace Safety Under Australian Law)

Atorvastatin may impact cognitive functions, potentially leading to dizziness or drowsiness. This could raise concerns regarding activities that require full alertness, such as driving or operating heavy machinery. Under Australian law, patients on prescription medications must be able to safely engage in these activities. If there are experiences of impaired function, it’s imperative to avoid driving and consult with a healthcare professional for advice.

For those working in safety-sensitive jobs, particular attention to workplace safety under Australian regulations is crucial. Tasks involving physical exertion or high-stakes decision-making may be compromised if side effects arise from atorvastatin. Always keep employers informed of medication use to ensure safety protocols are followed, especially if side effects manifest.

Q&A — “Can I Drive After Taking It In Australia?”

Q: Can I drive after taking atorvastatin in Australia?
A: If you experience dizziness or fatigue, it's best to avoid driving and consult your doctor.

INN, brand names available in Australia

When considering atorvastatin, you'll find a range of brand names and packaging available in Australia. The most commonly recognised brand is Lipitor, which dominates the market. However, there are several generic alternatives, often marketed under names like Apo-atorvastatin. This variety makes it easier for patients to choose options that fit their budget and preferences. Common strengths for atorvastatin include:

• 10 mg
• 20 mg
• 40 mg
• 80 mg

Packaging can vary, with some options available in blister packs, while others may come in bottles. Each strength caters to different dosage needs, which allows for individualised treatment plans. Such flexibility can aid in managing cholesterol levels effectively and safely.

Legal classification (TGA-approved, PBS-listed)

Atorvastatin enjoys approval from the Therapeutic Goods Administration (TGA) in Australia. This status signifies that it meets stringent safety and efficacy standards. Moreover, atorvastatin is listed on the Pharmaceutical Benefits Scheme (PBS). This listing significantly impacts affordability for patients, ensuring it remains accessible.

Subsidised pricing on PBS means that many patients won't bear the full cost of atorvastatin, thereby reducing out-of-pocket expenses. This classifies atorvastatin as a crucial medication in managing cardiovascular health, allowing for better compliance and treatment adherence in patients.

Dosing Guide

Standard regimens (PBS reference dosing)

Understanding the dosing guidelines for atorvastatin is essential for effective treatment and management of cholesterol levels.

According to the Pharmaceutical Benefits Scheme (PBS) in Australia, the typical dosage for adults includes:

• Initial dose: 10 mg to 80 mg orally once daily.
• Maintenance dosage: 10 mg to 80 mg depending on specific cholesterol target levels and patient response.

For different populations, such as the elderly, it’s crucial to exercise caution. Doses may begin on the lower end to assess tolerance, especially considering potential renal impairment.

In addition, specific populations, like adolescents or those with concurrent conditions, may experience variations in dosing, requiring careful monitoring and adjustments.

Adjustments for comorbidities

Patients with renal impairment are at higher risk while taking atorvastatin. A dosage adjustment is often necessary.

• For moderate renal impairment, a lower starting dose is advised, with careful monitoring.
• Severe renal impairment typically necessitates cessation of atorvastatin, particularly if eGFR levels drop below 30 mL/min.

Those with hepatic impairment must also consult healthcare professionals before commencing atorvastatin.

Renal and liver function should be regularly assessed to ensure the dosage remains appropriate and safe.

Q&A — “What if I miss a dose?”

Q: What should I do if I miss a dose of atorvastatin?

A: Take it as soon as you remember unless it’s nearly time for your next dose.

Delivery Information for Atorvastatin