Basic Monodur Information

• INN (International Nonproprietary Name): Isosorbide mononitrate
• Brand names available in Australia: Monodur, Monoket
• ATC Code: C01DA14
• Forms & dosages: Tablets (10 mg, 20 mg, 40 mg, 60 mg)
• Manufacturers in Australia: Bayer AG, Atno Pharmaceuticals
• Registration status in Australia: Prescription Only
• OTC / Rx classification: Prescription Only (Rx)

Critical Warnings & Restrictions

Monodur, also known as isosorbide mononitrate, is generally effective for treating angina, but certain populations face specific risks associated with its use. Special care must be taken when prescribing this medication to high-risk groups such as the elderly, pregnant women, and individuals with chronic illnesses.

High-Risk Groups (Elderly, Pregnancy, Chronic Illness)

Patients in these categories may experience heightened sensitivity to the side effects of Monodur. The elderly, in particular, may have age-related physiological changes that can lead to increased susceptibility to complications, including hypotension and dizziness. Pregnant women should consult healthcare professionals prior to use, as the impacts on foetal health must be considered. Patients with chronic illnesses such as renal or hepatic impairment also warrant additional medical supervision; any underlying health issues could exacerbate side effects or decrease the effectiveness of the medication.

Interaction With Activities (Driving, Workplace Safety Under Australian Law)

Monodur can impair cognitive and motor skills, which raises concerns for activities requiring full attention, such as driving or operating machinery. In Australia, workplace safety regulations mandate that employees must not be adversely affected by medications while performing their duties. It is essential for those taking Monodur to be aware of their individual responses to the medication before engaging in such activities. If feeling light-headed or drowsy after taking Monodur, it is advisable to refrain from activities that could endanger oneself or others.

Q&A — “Can I Drive After Taking It in Australia?”

In short, the ability to drive after taking Monodur depends on how the individual responds to the medication. For personalised advice, it is best to consult with a healthcare professional. They can provide guidance based on your specific health conditions and treatment plan.

INN, brand names available in Australia

Monodur is the brand name for isosorbide mononitrate, a medication commonly used in the management of angina pectoris.

This drug goes by different brand names in various regions, with Monoket being one of the most recognized brands. It's essential to know that while Monodur 60 mg may be highlighted, the medication is available in various formulations and strengths tailored to patient needs, such as:

• Immediate-release tablets (10 mg, 20 mg)
• Extended-release tablets (40 mg, 60 mg)

In Australia, the presence of these brand names showcases the international breadth of isosorbide mononitrate’s availability.

While Monoket dominates the branding in many countries, other names like Dinitron, Imdur, and Ismo are employed elsewhere. The packaging typically includes blister packs containing 20, 30, or even 100 tablets, catering to the various ways patients consume their medications.

Furthermore, its distribution reflects not only its efficacy but also the global recognition of its therapeutic importance as part of cardiac therapy.

Legal classification (TGA-approved, PBS-listed)

The legal pathway for medications like Monodur ensures that patients receive quality, efficacious products. In Australia, Monodur is classified as a prescription-only medication and has secured approval from the Therapeutic Goods Administration (TGA).

This regulatory status signifies that Monodur must be prescribed by a healthcare professional, ensuring a considered approach to its use, particularly for individuals managing chronic conditions like angina.

Additionally, it is listed on the Pharmaceutical Benefits Scheme (PBS), meaning patients can access Monodur at a subsidised cost. This arrangement facilitates better healthcare accessibility, allowing those who truly need the drug to obtain it without financial hardship.

The PBS listing also implies that healthcare providers can confidently prescribe Monodur, knowing it meets stringent safety and efficacy standards. This is particularly vital in a climate where patients are increasingly concerned about the cost of medications and the importance of effective treatment regimens.

Critical factors regarding Monodur's legal classification are:

• **TGA Approval:** This confirms that Monodur meets Australian health standards.
• **PBS Listing:** Provides financial relief and access for eligible patients.

With these classifications in place, Monodur stands as a reliable option for those managing heart-related conditions, offering both therapeutic benefits and access assurance for Australian patients.

Dosing Guide

Standard regimens (PBS reference dosing)

Understanding dosages for medications like Monoket, which contains isosorbide mononitrate, is essential for effective treatment. According to the Pharmaceutical Benefits Scheme (PBS), here’s a breakdown for standard indications like angina:

• Initial Dose: For the prevention of angina, start with 20 mg of isosorbide mononitrate once or twice daily.
• Maintenance Dose: Depending on the patient's response, this can increase to 40 mg administered twice daily with immediate-release tablets or 40–60 mg once daily with extended-release tablets.

It's vital to allow a 7-hour gap between doses to mitigate the risk of developing tolerance, ensuring that the medication remains effective.

Adjustments for comorbidities

For specific patient groups, adjustments may be necessary. Here’s a handy overview:

• Elderly: No formal dosage adjustments but start at the lowest effective dose and monitor for hypotension.
• Renal impairment: Use caution; while no specific adjustments are mandated, close monitoring is wise.
• Hepatic impairment: Marked liver dysfunction may require a lower starting dose due to increased hypotension risk.

Always consider any potential contraindications these patients may have, as they can significantly influence treatment outcomes.

Q&A — “What if I miss a dose?”

If a dose is missed, it’s advisable to take it as soon as it’s remembered unless it’s less than 4 hours until the next scheduled dose; in that case, skip it entirely. Doubling up on doses is not recommended. For overdoses, signs like severe hypotension or tachycardia may manifest, and supportive management should be sought immediately—hospitalisation might be necessary for effective care.

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