Basic Prometrium Information

• International Nonproprietary Name (INN): Progesterone
• Brand Names Available in Australia: Prometrium
• ATC Code: G03DA04
• Forms & Dosages: Capsules (100 mg, 200 mg)
• Manufacturers in Australia: AbbVie
• Registration Status in Australia: Prescription only (Rx)

Critical Warnings & Restrictions

Prometrium is a prescription medication that contains micronised progesterone. This treatment does come with specific safety risks that every patient should be made aware of. There are several absolute contraindications associated with its use, including:

• Severe liver dysfunction
• Known or suspected breast cancer
• Unexplained abnormal vaginal bleeding

Patients with a history of thrombosis, such as deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, or myocardial infarction (MI) should also avoid Prometrium. Additionally, people who have severe allergies to peanut oil need to exercise caution, as some capsules are formulated with this ingredient.

High-Risk Groups

Certain groups are particularly vulnerable when it comes to using Prometrium. Individuals who are elderly, pregnant, or have chronic health conditions should consult their healthcare provider before commencing treatment. Due to potential complications such as liver issues or cardiac events, ongoing monitoring is strongly advised for these groups.

Interaction with Activities

Patients taking Prometrium may sometimes experience dizziness or drowsiness. These side effects can significantly influence the ability to perform activities that require alertness, such as driving or operating heavy machinery. Per Australian law, any medications that impair these capabilities must be disclosed to ensure safety and proper guidance.

Q&A — “Can I Drive After Taking It in Australia?”

- Q: Can I drive after taking Prometrium? - A: It depends on how you feel. If you experience dizziness or drowsiness, it's best to refrain from driving. Managing your treatment with Prometrium requires awareness of these critical warnings and restrictions. Understanding potential risks ensures a safer experience whether initiating treatment for secondary amenorrhea, endometrial protection alongside estrogen, or other recommended uses. Always engage in conversations with healthcare professionals to ensure that therapy aligns effectively with individual health needs. If you're contemplating obtaining Prometrium, it's always a good idea to consider all available options and weigh the benefits alongside potential risks. Options like alternative progesterone therapies may provide similarly effective results depending on your specific health profile and concerns. Make an informed choice regarding your health, and remember, when in doubt, consult with your healthcare provider for advice tailored to your unique situation.

Mechanism & Pharmacology

Prometrium operates through its active ingredient, micronised progesterone, which plays a crucial role in regulating menstrual cycles and supporting fertility. This compound mimics the hormone produced naturally in the body, helping to stabilise the uterine lining and alleviate symptoms related to hormone imbalance.

Simplified Explanation

In basic terms, Prometrium works by counteracting the effects of oestrogen, ensuring the uterus is ready for possible implantation during the menstrual cycle. This interaction is vital, particularly for individuals undergoing hormone replacement therapy (HRT).

Clinical Terms

From a medical perspective, the pharmacodynamics of Prometrium involves its binding to progesterone receptors. This mechanism is essential for promoting endometrial development and maintaining regularity in menstrual cycles. Healthcare providers must grasp this mechanism to safely prescribe Prometrium effectively.

Indications & Off-Label Uses

The Therapeutic Goods Administration (TGA) has approved Prometrium for conditions such as secondary amenorrhea and as supportive therapy for postmenopausal women using oestrogen. Its effectiveness in preventing endometrial hyperplasia when combined with oestrogen therapy is well documented.

Off-Label Uses in Australian Clinical Practice

Clinically, Prometrium is often used off-label to manage issues like premenstrual dysphoric disorder (PMDD) and certain fertility challenges. While these applications can be beneficial, they should always occur under a healthcare provider’s discretion to ensure proper monitoring and support.

Key Clinical Findings

Recent studies conducted between 2022 and 2025, both in Australia and worldwide, have highlighted the effectiveness of Prometrium in alleviating menopausal symptoms and maintaining uterine health during HRT. These findings reinforce its reliability as a therapeutic option for individuals experiencing hormone imbalances.

Clinical trials continue to evaluate its long-term effectiveness and safety profile, helping to optimise its use for patient benefit.

Alternatives Matrix

There are several alternatives to Prometrium, including other forms of progesterone and progestins like Medroxyprogesterone (Provera) and Dydrogesterone (Duphaston).

PBS-Listed Alternatives Comparison Table

Alternative	Formulation Type	Key Distinction
Provera	Tablet/IM	Synthetic progestin available in various forms
Duphaston	Oral	Synthetic but chemically distinct from Prometrium
Utrogestan	Softgel	Micronised form with similar usage

This comparison helps patients and healthcare practitioners identify suitable options while considering the pros and cons based on individual health needs.

Pros and Cons Checklist

• Pros: Effective symptom relief, variety of formulations.
• Cons: Side effects may vary; not suitable for everyone.

Common Questions

When discussing Prometrium, patients commonly have several queries, particularly during pharmacy consultations about its use in treatment plans.

FAQs from Australian Pharmacy Consultations

Q: "How should I take Prometrium for the best results?"

A: It's recommended to take Prometrium at bedtime due to its potential to cause drowsiness. Always follow your healthcare provider’s specific advice.

Q: "What should I do if I forget to take it?"

A: If a dose is missed, take it as soon as remembered unless it’s close to the next dose. In that case, skip the missed dose and continue as normal.

Suggested Visual Content

Visual materials promoting Prometrium could include infographics outlining its PBS pricing and accessibility, providing insight into its role in the Australian healthcare system.

Infographics: PBS Pricing, Pharmacy Network Map

Clear visual content will enhance patient understanding and aid in locating pharmacies, particularly for those in rural areas or those seeking Prometrium through available networks.

Registration & Regulation

Prometrium holds TGA approval and is classified for specific conditions, underscoring its importance in hormone therapy. Its listing under the Pharmaceutical Benefits Scheme (PBS) promotes affordability, making it a cornerstone for hormonal management in Australian women.

PBS Subsidy Details

The subsidy under the PBS allows patients to access Prometrium at reduced prices. Since costs may fluctuate, consumers are advised to check regularly for updates on subsidy information.

Storage & Handling

Proper storage of Prometrium is paramount to maintain its efficacy. In Australia, it is advised to store below 25°C (77°F). Keeping it out of moisture and light exposure is essential to prevent degradation.

Household Storage in Australian Climate (Heat/Humidity)

Given Australia's varying climate conditions, particularly heat and humidity, safeguarding medications is vital for their effectiveness. To help ensure that Prometrium remains potent:

• Store capsules in a cool, dry place away from direct sunlight.
• Check expiry dates regularly.
• Keep capsules in their original packaging to protect them from moisture and light.

These tips help in ensuring the medication remains in good condition, crucial for those who rely on it for hormone replacement therapy.

Cold-Chain Handling for Pharmacies

Pharmacies must comply with specific cold-chain management standards to retain Prometrium's product integrity. This means maintaining the right temperature throughout storage and transportation processes. Patients can feel confident that when they purchase their prescriptions, the product has been stored properly to maintain its quality.

Guidelines for Proper Use

Training in pharmacist counselling styles promotes proper understanding among patients on how to utilise Prometrium effectively. Clear guidance on dosing schedules, potential interactions, and side effects should be part of consultations for optimal medication management.

Patient Advice from PBS and National Health Authorities

Patients should be informed about the importance of adhering to prescribed regimens. Key points include:

• Discussing any side effects with their pharmacists to optimise therapies.
• Exploring integration of Prometrium with lifestyle factors, such as diet or other medications.

Guidelines provided by PBS and national health authorities emphasise that awareness is crucial for making the most of hormone replacement therapies, minimising risks while deriving the greatest benefit from Prometrium.

City	Region	Delivery Time
Sydney	New South Wales	5–7 days
Melbourne	Victoria	5–7 days
Brisbane	Queensland	5–7 days
Perth	Western Australia	5–7 days
Adelaide	South Australia	5–7 days
Hobart	Tasmania	5–9 days
Canberra	Australian Capital Territory	5–7 days
Gold Coast	Queensland	5–9 days
Newcastle	New South Wales	5–9 days
Wollongong	New South Wales	5–9 days
Cairns	Queensland	5–9 days
Sunshine Coast	Queensland	5–9 days